Thursday, September 3, 2020

Diary of A Teenage Girl. Becoming Me Essay Example For Students

Journal of A Teenage Girl. Turning out to be Me Essay Journal of A Teenage Girl. Turning out to be MeTitle Page: On the front of Diary of a Teenage Girl, Becoming Me there is a young lady with long sleek earthy colored hair. I get the feeling that she is dismal or lost since she is whirling her hair in the middle of her fingers. Her head might be inclined down in a discouraged movement. I think her hands are the main thing obvious on the grounds that the creator is attempting to set of the temperament of th little youngster, and I think this is appeared by the spinning of the hair between the fingers. Distribution Data: Carlson, Melody. Journal of a Teenage Girl, Becoming Me. (US of America, Multonomach Publishers, 2000)Setting: The setting is the time and spot of a stories activities. The setting in this novel is New Jersey. Three explicit subtleties of this setting are: a.) Caitlin and her family live in a little, thin duplex with 3 rooms and one restroom; b.) their home is focal New Jersey and situated close to a huge park; c.) the house is a light earthy colored with cream shaded screens and has two enormous entryways in the front. Caitlin and her family live in the duplex with one other family in spite of the fact that the duplex has three stories. Living focal permits Caitlin and her family simple access to class, church and work. She can go to olympic style events after school and spend time with her companions at the nearby coffee shop. Caitlin studies herself by adventuring out into New Jersey and going to youth bunch however much as could be expected, becoming familiar w ith God. Plot: Plot is a progression of episodes which give a strong system to the improvement of a stories strife. Strife is a battle between two contradicting powers. The primary clash in this novel is man versus himself. Caitlin battles to locate her actual self and become familiar with her religion. She settles on numerous decisions all through he novel that will affect her life for eternity. The contention starts when Caitlin begins being progressively brave and starts going to gatherings and spending time with an inappropriate group that she believes are the cool children. She meets new individuals that arent her actual companions and arent great individuals. These individuals attempt to get her to do things that she truly doesnt need to do and she settles on the correct decision in saying No. She quickly goes into a room where she cannot be constrained and chooses not to spend time with those individuals any longer. After she has had a portion of this awful condition she understands who her actual companions are and she returns to them. She settles on numerous shrewd decisions in the following up and coming occasions, and is prepared to manage those sorts os circumstances. Characters: The three physical qualities of Caitlin are a.) long, straight, luxurious earthy colored hair; b.) large earthy colored eyes; c.) and she is around 54 meters tall. The three mental qualities of Caitlin are a.)she is brilliant and passing marks in school; b.)she is an extremely solid headed individual; c.) she is exceptionally faithful to God. Caitlin is an awesome understudy and shows this purchase getting passing marks at school and going to routinely, doing whatever it takes not to miss a day. She is likewise exceptionally faithful to her olympic style sports group and his extremely committed. She is solid headed and represents what she has faith in. She gets a kick out of the chance to contend with individuals until she has come to her meaningful conclusion. She is additionally faithful to God and keeps up to be a decent Christian. She exhibits this all through the whole novel as she stays to be a virgin until she is hitched, not celebrating and going to chapel and youth bunch as regularly as could be expected under the circumstances. .u225e412eb084cbf0553ac11604829dce , .u225e412eb084cbf0553ac11604829dce .postImageUrl , .u225e412eb084cbf0553ac11604829dce .focused content zone { min-tallness: 80px; position: relative; } .u225e412eb084cbf0553ac11604829dce , .u225e412eb084cbf0553ac11604829dce:hover , .u225e412eb084cbf0553ac11604829dce:visited , .u225e412eb084cbf0553ac11604829dce:active { border:0!important; } .u225e412eb084cbf0553ac11604829dce .clearfix:after { content: ; show: table; clear: both; } .u225e412eb084cbf0553ac11604829dce { show: square; change: foundation shading 250ms; webkit-progress: foundation shading 250ms; width: 100%; obscurity: 1; progress: mistiness 250ms; webkit-progress: murkiness 250ms; foundation shading: #95A5A6; } .u225e412eb084cbf0553ac11604829dce:active , .u225e412eb084cbf0553ac11604829dce:hover { darkness: 1; change: haziness 250ms; webkit-change: obscurity 250ms; foundation shading: #2C3E50; } .u225e412eb084cbf0553ac11604829dce .focused content zone { width: 100%; position: relative; } .u225e412eb084cbf0553ac11604829dce .ctaText { fringe base: 0 strong #fff; shading: #2980B9; text dimension: 16px; textual style weight: striking; edge: 0; cushioning: 0; text-improvement: underline; } .u225e412eb084cbf0553ac11604829dce .postTitle { shading: #FFFFFF; text dimension: 16px; textual style weight: 600; edge: 0; cushioning: 0; width: 100%; } .u225e412eb084cbf0553ac11604829dce .ctaButton { foundation shading: #7F8C8D!important; shading: #2980B9; outskirt: none; outskirt sweep: 3px; box-shadow: none; text dimension: 14px; text style weight: intense; line-stature: 26px; moz-fringe span: 3px; text-adjust: focus; text-beautification: none; text-shadow: none; width: 80px; min-stature: 80px; foundation: url( arrow.png)no-rehash; position: total; right: 0; top: 0; } .u225e412eb084cbf0553ac11604829dce:hover .ctaButton { foundation shading: #34495E!important; } .u225e412eb084cbf0553ac1160482 9dce .focused content { show: table; stature: 80px; cushioning left: 18px; top: 0; } .u225e412eb084cbf0553ac11604829dce-content { show: table-cell; edge: 0; cushioning: 0; cushioning right: 108px; position: relative; vertical-adjust: center; width: 100%; } .u225e412eb084cbf0553ac11604829dce:after { content: ; show: square; clear: both; } READ: Brandon Hill: My Personal Art Collection EssayThe three physical qualities about Beanie are a.) she is extremely short; b.)she has long dark hair that scopes past her butt; c.) she has little earthy colored eyes. The three physical qualities of Beanie are; a.)she is athletic; b.) she, as Caitlin, is extremely hardheaded; c.) and she is exceptionally savvy. Beanie is an athletic individual and appreciates olympic style events after school. She is an exceptionally serious sprinter and is probably the best competitor at running long bounce. Beanie is additionally extremely persistent and will express her real thoughts anytime. She isn't reluctant to express her genuine thoughts to her mom and doesnt permit anybody to put down her in any capacity. Beanie is additionally keen and gets incredible evaluations in school. She goes to consistently and adores English and Social Sciences. Topic: The subject that the creator is exhibiting in this novel is that we as individuals must defend what we put stock in. We should be knowledgeable in out convictions and have the option to back them up with a solid contention. The writer causes us as perusers to understand that try not to be embarrassed about what your identity is and what you put stock in. The creator likewise gives us that an individual who is energetic in what they have confidence in can be effective and accomplish extraordinary achievements. This thought is unmistakably indicated when Caitlin turns out to be exceptionally upbeat when she discovers God. She accepts that he is the response to everything, and that she should observe every one of his guidelines so as to be a decent Christian. She is cautious and insightful in all the decisions that she settles on, she realizes that each and every decision will impact her future. I accept that the creator shows topic obviously in this novel. Caitlin is a decent Christian and submits to all the standards that God has given her. She doesnt go to gatherings and drink, and she is sparing her virginity until she is hitched. This shows she is exceptionally committed, steadfast and is keeping solid with her dedication. Besides this leads Caitlin to an extraordinary future in reporting, where she turns out to be extremely fruitful and focussed. Gratefulness: One thing that I enjoyed about this bok was that it was a diary of a high school young lady who is managing genuine adolescent issues. It discusses going to parties, drinking, tranquilizes, and even sex, that we as teenagers are managing. I additionally like how the creator made Caitlin a resilient individual in that she settles on insightful decisions and is adult. Those are excellent characteristics that more adolescents need nowadays. One thing that I didnt like about this book anyway was that it gabbed about God. Going into this novel I thought it would have been all the more energizing then it really was. I thought Caitlin would have a good time more and have a ton of fun. Well at any rate as I would see it, have a great time then she did. I didnt like the way that Caitlin just couldnt unwind, she imagined that God didnt need her to have a great time by any means. I likewise feel that the creator ought to have put Caitlin in progressively hazardous circumstances, for example, drinking and medications, so Caitlin would have the decision. In the book she didnt even attempt any of these things to demonstrate her that she really needed to be with God. I feel that she expected to have more fun all through the book. Proposal: I would prescribe this novel to anybody that is keen on God, and who needs to be a superior Christian. This tale may pull in a peruser that is into news-casting themselves and who is a solid head ed individual. By the by this novel is coordinated more towards more youthful perusers who are encountering the issues of todays teenagers.

Saturday, August 22, 2020

Effect of Media on Eating Habits Essay Example for Free

Impact of Media on Eating Habits Essay Presently this is a genuine and developing worry for general wellbeing authorities, enlisted dietitians, and families keen on living their everyday lives in a sound way. Youth are at the most elevated hazard. As indicated by the National Health Examination Survey, kids ages 11-13 have most elevated pace of day by day TV seeing (Brown, 2008, p. 316). In a recent report, youngsters were bound to be overweight when they observed more TV (Gable, Chang Krull, 2007). Right now, the subsequent driving reason for real passing as per the Center for Disease Control and Prevention is less than stellar eating routine and physical idleness (Schneider, 2006, p. 270). Patterns that lead to terrible eating routine and physical inertia, in the long run corpulence in grown-ups and youngsters the same, come from propensities that structure right off the bat in adolescence. This makes an interminable cycle that sustains from age to age. Stoutness is right now an issue that undermines most of Americans and its pervasiveness has expanded significantly over the most recent three decades (Schneider, 2006, p. 72). It’s brought about by various elements including hereditary qualities, physical inertia, and poor dietary patterns. Two of the three variables noted can be firmly connected with TV media. An examination led at the University of Minnesota in 2009 found an expanded occurrence of eating before the TV was fundamentally because of publicizing and decreased metabolic rate in puberty (Barr-Anderson, Larson Nelson, 2009). Diminished metabolic rate diminishes one’s requirement for calories. People of this segment regularly don’t think about this reality and eat as much as before their presentation to TV was such a critical piece of their day by day schedule. This propensity prompts undesirable and superfluous weight gain. Expanded weight has appeared to hoist the danger of cardiovascular infection, diabetes and most sorts of malignant growth also corpulence (Schneider, 2006, p. 270). A less regularly perceived marvels identified with this issue is that individuals don’t comprehend what solid decisions are and thus, they are bound to succumb to any enticements set before them. These allures are given most regularly by TV media promoting coordinated at less instructed, all the more handily affected crowds. For instance, cheap inexpensive food that is an especially famous sort of publicizing may appear to be a legitimate wellspring of nourishment for certain families that don't approach, or realize anything better. Condition There are numerous issues that make up this mind boggling and layered circumstance. Numerous social, social and monetary elements add to these dietary examples and dietary patterns that create over a lifetime (Schneider, 2006, p. 77). The measure of time kids go through with various wellsprings of media from: TV, film, computer games, and PC or online media is exceedingly taking up most of their time. With the normal five and a half hours youngsters spend utilizing media consistently, the main thing they invest more energy doing is resting (Henry J. Kaiser Family Foundation, 2004). From age two to twenty, just eighteen years, that signif ies more than 29,900 hours went through with media and 1. multiple times more than the 16,000 hours spent in school grades k-12 (Grossberg, 2006, p. 93). That equivalents out to roughly 20 hours out of each week as indicated by an investigation done in 2006 (Francis Birch, 2006). Not just in the time spent presented to media is a hazard factor for kids, yet the manner by which the media is expended is additionally a significant supporter of this circumstance. In the home, if there is an absence of parental control observing children’s media presentation, youngsters are then at a higher danger of being impacted. Youngsters vigorously impacted by the media can control how cash is spent and wise organizations consider them to be the customers to be focused on (Peregrin, 2001, p. 6). Youngsters now and then even spend their own cash on the items they see over and over strengthened around them. Publicists utilize this verifiable truth to target youngsters since they know the ground-breaking impact kids can have on their folks buying choices (Peregrin, 2001, p. 56). In an article written in 2001, Registered Dietitian, Adrienne Dorf c ommunicated her sentiment about teaching youngsters who are presented to over the top media. She underscored the need to clarify the contrast between TV projects and plugs to kids who will most likely be unable to separate the two. Dorf asked guardians to clarify the possibility of deals and the way that the food publicized by means of plugs may not be the best for our bodies. Dietary propensities structure over a lifetime and are extraordinarily affected by the social condition and family setting just as the media (Schneider, 2006, p. 277). Now and again guardians battle with bringing their youngsters into the general store for staple goods since they don’t need to quarrel over what the new furor is in sweet oat or what unfortunate nibble wafers are indicating more advertisements on TV or the most recent animation characters face on their container. It is a typical to see a mother or father who yields to satisfy their youngster when the person in question pitches a fit in the path to get something they need. This rehashed activity can be an adverse over the long haul on the off chance that it endures and proceeds. Effect Food ventures have an objective to sell however much of their item to the general population as could reasonably be expected. They will do anything they can to urge American’s to eat and spend more cash on any of their items. Most food promoted is high in fat, sugar, and salt prompting youngsters in the market asking their folks for candy and undesirable nibble nourishments (Borzekowski Robinson, 2001). Nourishments promoted taste â€Å"good† bringing about commercials publicizing food sources with high measures of sugar, fat, and salt towards more youthful ages. For instance, quick nourishments and high sugar grains are two of the most normally plugged things during children’s programming. Studies have demonstrated that kids younger than 6 years old can't recognize TV programming instead of business publicizing (Borzekowski Robinson, 2001). The essential issue is that youngsters who invest inordinate measures of energy presented to TV media are bound to be overweight. As indicated by the National Longitudinal Survey of Labor Market Experience, Youth Cohort (NLSY) a solid portion reaction relationship was found between TV seeing and the commonness of overweight (Brown, 2008, p. 316). Young people from 10 to 15 years of age who detailed observing over 5 hours of TV for every day had more noteworthy chances of having a BMI in the 85th percentile (Brown, 2008, p. 316).

Friday, August 21, 2020

Introduction To Contextual Study Of Nestle Marketing Essay

Prologue To Contextual Study Of Nestle Marketing Essay Nestlã © Company had begun from a solitary keeps an eye on thought, and formed into a goliath partnership. In 1866 Henri Nestlã ©, a drug specialist, built up a milk food recipe for newborn children who couldn't endure their mom milk ( His item turned into a triumph, and it made an interest all through Europe. As Nestlã ©s fame developed more organizations needed to consolidate and become accomplices with Henri Nestlã ©s business. From 1866 to 1947 the Nestlã © Company had experienced a few name changes. In 1905, Anglo-Swiss Condensed Milk Co. what's more, Farine Lactee Henri Nestlã © combined, and the companys name became Nestlã © Anglo-Swiss Condensed Milk Co. At that point in 1929, Peter-Cailler-Kohler Chocolats Suisses S.A. converged with the organization. The name was then changed to Nestlã © Anglo-Swiss Holding Co. Ltd, on November 27, 1936. In December 1947, Co. obtained all the offers capital of the Alimentana S.A. organization in return for fifteen Nestlã © offers and fifteen Unilac shares for each of Alimentana S.A. share, so this point the name was at Nestlã © Alimentana S.A. And afterward at long last, the last name change that the organization would suffer was in 1977, where it embraced the name Nestlã © SA (Mergent Online). The dairy items at Nestlã © are a major main impetus for the development of the companys deals. With the wellbeing kick of the numerous people far and wide, it pushes the trailblazer and renovators of Nestlã © to arrive at new tallness in discovering better and more advantageous items for their shoppers. In 1998, the dairy business had represented 5% of the companys deals income (Rodgers, 2000). Later, in the primary portion of 2004, Nestlã © milk-based items, nourishment, and dessert represented 60% of Nestlã © income development ( The measure of 60% is a major part of the companys profit, so it would be best for Nestlã © to center a major segment of their center skills and assets on the quickly developing dairy division. Which drives us into the latest yogurt created by Nestlã ©s, which is the LC1. Nestlã © endeavors on being trend-setter and renovators. So their examination group in Switzerland found a culture called Lactobacillus acidophilus, or La-1. This specific item was picked in light of the fact that it contains a probiotic specialist, which is living microbial taking care of enhancements that permit the lower digestive system to work better (Rodgers, 2000). La-1 enables the small digestive tract to work by improving the bodys invulnerable framework, and thusly helping the body in forestalling sicknesses. Nestlã © has now discovered an answer for their wellbeing cognizant shoppers, however now they have to discover away to actualize it into one of their items. That when the scientists at Nestlã © found that on the off chance that they supplant one of the blends in their yogurt with the La-1 a similar surface would be kept up. Presently with the blend of Nestlã © yogurt blend and the La-1; Nestlã © has given their yogurt the name of LC1. Decentralization Switzerland is home to Nestles Swiss auxiliary, its worldwide central command and the enrolled office of Nestles holding organization, however Nestle doesn't view its Swiss home office as the focal point of the universe. Decentralization is a fundamental guideline of Nestle. Their approach is to adjust however much as could be expected to territorial conditions, attitudes and circumstances. By decentralizing operational obligation, they make quality and adaptability and can settle on choices that are better receptive to explicit circumstances in a given nation. Approaches and choices concerning faculty, showcasing and items are to a great extent decided locally. This strategy makes more grounded inspiration for Nestles administrators and workers and a more prominent feeling of recognizable proof with Nestles business. It isn't Nestles arrangement to create the greater part of its deals in Switzerland, enhanced by a couple of satellite auxiliaries abroad. Settle endeavors to be an ins ider in each nation in which it works, not an outcast. ' Innovative work Settle is most likely one of a kind in the food business in having a coordinated innovative work program that takes part in applied and essential research in the fields of human physiology, wellbeing, nourishment and crude materials. Their innovative work program enables them to make new kinds of items that they can't envision today, particularly in the basic region where preventive medication and food items cover. Also, as worry for nature develops, research will assume a significant job in conquering ecological issues. For Nestle this is especially significant in bundling. While Nestlã © Corporate Business Principlesâ will proceed to advance and adjust to an evolving world, their fundamental establishment is unaltered from the hour of the inceptions of Company, and mirrors the essential thoughts of reasonableness, trustworthiness, and a general worry for individuals. Nestlã © is focused on the accompanying Business Principles in all nations, considering nearby enactment, social and strict practices: Nestlã ©s business objective is to make and market the Companys items so as to make esteem that can be supported over the long haul for investors, representatives, customers, and colleagues. Nestlã © doesn't support momentary benefit to the detriment of effective long haul business improvement. Nestlã © perceives that its purchasers have a true and genuine enthusiasm for the conduct, convictions and activities of the Company behind brands in which they place their trust, and that without its customers the Company would not exist. Nestlã © accepts that, when in doubt, enactment is the best protect of capable lead, in spite of the fact that in specific regions, extra direction to staff as willful business standards is gainful so as to guarantee that the best expectations are met all through the association. Nestlã © is aware of the way that the achievement of an organization is an impression of the polished methodology, direct and the mindful mentality of its administration and workers. In this way enlistment of the perfect individuals and progressing preparing and improvement are critical. Nestlã © keeps on keeping up its promise to follow and regard all material nearby laws in every one of its business sectors. In Nestlã ©s see, it must be completely incorporated in the social, social and monetary texture of the nations in which it works. Along these lines regardless of which nation it works in, it is focused on reinforcing nearby networks. VISION AND STRATEGY The Nestlã © worldwide vision is to be the main wellbeing, health, and sustenance organization on the planet. Nestlã © Pakistan buys in completely to this vision. Specifically, we imagine to: Lead a unique spurred and expert workforce pleased with its legacy and bullish about what's to come. Meet the wholesome needs of buyers of all age bunches from outset to mature age, from sustenance to joy, through a creative arrangement of marked food and drink results of the highest caliber. Convey investor esteem through gainful long haul development, while proceeding to play a critical and dependable job in the social, monetary and natural parts of the nation. Our brands are the favored decision in their classes. Customer knowledge drives all parts of our promoting and correspondence endeavors. Our correspondences to the shopper are pertinent, bleeding edge, and hold fast to the best expectations of mindful correspondence. Our organization is viewed as the No. 1 vocation goal for skilled, spurred and goal-oriented experts. Our outcome arranged hierarchical structure guarantees compelling correspondence and enabled self-administration. Our milk assortment and agri administrations will keep on assuming the essential job being developed of the dairy segment in country Pakistan. Our proactive development and remodel culture is the way in to our achievement in the commercial center. Completely incorporated frameworks (Nestlã © Pakistan, providers, clients) guarantee productive business forms. Non-key exercises and items are redistributed or suspended. Home office: Greenwich, CT, USA Brands: 14 Identified with: Nestlã © Waters, Paris, France, an auxiliary of Nestlã ©, S.A., Vevey, Switzerland Items Nestlã © has a wide scope of items over various markets including espresso (Nescafã ©), filtered water, different refreshments, chocolate, dessert, newborn child nourishments, execution and medicinal services sustenance, seasonings, solidified and refrigerated nourishments, candy store and pet food. Business sections Drinks Milk Products, Nutritional, and Ice Cream Arranged Dishes and Cooking Aides Sweet shop Other Food Beverages Pet Care Pharmaceutical Products Settle Pakistan Milestone In 1912 Nestle starts its involved acquaintance with South Asia when the settle Anglo-Swiss consolidated Milk organization begins bringing in and selling completed items in the Indian market. Settle clarifies a qualification among system and strategies. It offers need to the long-extend see. Long haul thinking defuses huge numbers of the contentions and disputes among bunches this applies to business conditions and relations with workers just as to the contentions and restricting interests of the exchange and the business. Obviously, capacity to concentrate on long haul contemplations is just conceivable if the organization is effective in the battle for momentary endurance. This is the reason Nestle endeavors to keep up a palatable degree of benefits each year. Nestlã © depicts itself as a food, nourishment, wellbeing, and health organization. As of late they made Nestlã © Nutrition, a worldwide business association intended to fortify the attention on their center sustenance business. They think reinforcing their initiative in this market is the key component of their corporate methodology. This market is described as one in which the shoppers essential inspiration for a buy is the cases distraught

Saturday, June 20, 2020

Schizophrenia A Review of DISC1 - Free Essay Example

Schizophrenia has yet to find its breakthrough treatment despite its global prevalence. The DISC1 proteins interactome role in neurodevelopment makes it a desirable target. Issues arise with the lack of structural data. DISC1 has been elusive until 2017 when the C-terminal domain complexed with Ndel1 was resolved with NMR. Psychotic disorders affect communities worldwide with the most common disorder being schizophrenia (Holder Wayhs, 2014), which is interesting to scientists and clinicians since there are currently no universally efficacious treatments (Willsey, et al., 2018). Part of what makes schizophrenia so difficult to treat comes from the complicated network of contributing factors that lead to onset including genetic, biochemical, and environmental influences on the person (Nascimento Martins-de-Souza, 2015). A person may also display many symptoms classified as positive or negative that require different treatments; positive symptoms include those which add to a persons behaviors like delusions, hallucinations, disorganized speech while negative includes those which remove a persons behaviors like catatonia and loss of emotional expression or motivation (Holder Wayhs, 2014). The symptoms are further complicated by the expense of treatments and by the tendency for a person to experience adverse effects from available treatments (Holder Wayhs, 2014). Proteomic (Nascimento Martins-de-Souza, 2015) and genetic studies (Devine, et al., 2016) have identified a slew of molecular targets with promising connection to the illness. One of these targets includes Disrupted-in-Schizophrenia 1, DISC1, a protein with incomplete characterization both functionally (Devine, et al., 2016) and structurally (Yerabham, et al., 2017). Mutations in the disc1 gene are linked to schizophrenia although it is important to consider that genome wide association studies do not confirm sole responsibility of Disc1 for the disorder (Devine, et al., 2016). Rather, it is the intracellular connectivity of the protein and the role of DISC1 in neurogenesis that makes the protein an attractive target for therapeutics (Ye, et al., 2017). The protein, DISC1, was identified when a Scottish family diagnosed with schizophrenia among other mental illnesses had their genome examined and found a translocation in disc1 where the gene located on chromosome 1 was found on chromosome 11, t(1:11) (Yerabham, et al., 2017). Attempts to define the structure of DISC1 have been limited due to its lack of homology to other known proteins and poorly conserved functional sequences (Millar, et al., 2005). A study by Millar, et al. (2005) predicted two major domains including an N-terminal head with conserved nuclear localization signals despite being poorly conserved otherwise and a C-terminus with a helical tail. Over 10 years later bioinformatics still only provided an estimation of structural disorder in the first 325 amino acids while the remaining 326-854 amino acids were helical or coiled (Yerabham, et al., 2017). Expression of Soluble Protein by Random Incremental Truncation (ESPRIT) of recombinant DISC1 in E. coli has led to the observation that DISC1 bears four consistently stable regions, D, I, S, and C from the N-terminal to the C-terminal ends of the protein, respectively (Yerabham, et al., 2017). Table 1 demonstrates the location of each region (Yerabham, et al., 2017). The D region is high in ? ±-helical content determined by circular dichroism (CD) and is the only region in the N-terminal; the I region displays structural qualities and CD also shows helical shape; the S region exhibits an elongated and helical form suggested by analytical ultracentrifugation (AUC) sedimentation velocity (SV) and CD, respectively; the C region also used AUC SV and CD to demonstrate an elongated and somewhat disordered helical shape (Yerabham, et al., 2017). Further, a study by Ye, et al. (2017) imaged the C-terminal tail when bound to Ndel1, a protein involved in mitosis and essential for proper neurodevelopment, with solution NMR to determine two ? ± -helical structures with atomic resolution. The DISC1-Ndel1 complex revealed a conserved antiparallel hairpin figure in DISC1 (Figure C) and when Ndel1 is bound it adds a third ? ±-helix to the 2-helix hairpin (Figure A) which produces a hydrophobic core (Figure G) (Ye, et al., 2017). DISC1 has the potential to assume many functional roles as there are hundreds of binding partners described (Ye, et al., 2017). The N-terminus was the focus of Millar, et al.s studies (2005) which used GFP- and V5-peptide tags for immunoprecipitation and immunofluorescent imaging to support mitochondrial targeting by the N-terminal domain of DISC1. Ye, et al.s (2017) investigation suggests the complex regulates Ndel1s kinetochore localization in HeLa cells by properly binding DISC1 to Ndel1 leading to timely mitosis. Radial glial cells (RGCs), relevant to the ventricular zone in neural stem cells of the embryonic cortex, were also tested in vivo using mouse models to test DISC1-Ndel1 function and revealed a regulating role for RGC cell-cycle progression as well (Ye, et al., 2017). Ye, et al. (2017) continued to examine DISC1-Ndel1 for roles in neurogenesis by testing human induced pluripotent stem cells (iPSCs) which were differentiated into forebrain-specific organoids and found reduced proliferation of neural stem cells when DISC1-Ndel1 binding was inhibited. Further, it was observed in forebrain-specific organoids containing the naturally occurring disc1 mutation that cell-cycle progression of RGCs throughout mitosis was delayed, confirming previous testing about DISC1-Ndel1 functions (Ye, et al., 2017). DISC1 has also been implicated in regulating dendritic N-methyl-D-aspartate receptor (NMDAR) dynamics which are necessary for synaptic plasticity and cognitive processes (Malavasi, et al., 201 8).

Monday, May 18, 2020

How to Set Up Classroom Learning Centers

Learning or rotation centers are places where students can self-direct their learning —usually in pairs or small groups—within the classroom. These designated spaces allow children to work collaboratively by accomplishing activities given an allotted amount of time and rotating to the next center after they have each completed a task. Learning centers also provide children with opportunities to practice hands-on skills and social interaction. Some classes have assigned spaces for learning centers all year while teachers in tighter classrooms set up and take them down as needed.  Permanent learning spaces are typically placed around the perimeter of the classroom or in nooks and alcoves where they dont interfere with the movement and flow of the classroom. No matter where a learning center is located or whether it is always standing, the only firm requirement is that it is a space in which children can work together to solve problems.   If youre ready to apply this popular tool to your teaching, read about how to effectively prepare the materials, arrange your classroom, and introduce your students to learning centers. Preparing the Centers The first step in creating a great learning center is to figure out what skills you want your students to learn or practice. Centers can be used for any subject but experiential learning and discovery should be the focus. Students need to be engaged even if they are practicing old skills. Once you have your focus, you can determine how many centers you will need and get to work designing and organizing them. Gather the materials, write out directions, and set behavioral expectations. Gather Student Materials You can pull materials from your curriculum or do a little digging if you dont think those will be engaging or meaningful enough. Scaffold the work that students will be doing and dont forget the graphic organizers. Put everything neatly in one place so you dont have to worry about materials management. Write out Clear Directions With Visuals Students should not need to raise their hand and ask you how to complete a task because the answers should already be there for them. Spend time designing task cards and anchor charts that provide step-by-step instructions so that you dont have to repeat yourself. Set Behavioral Goals and Expectations This one is especially important if your students have not had practice with learning centers. Teach them that they will need to cooperate with each other in order to learn and explain that most of their learning will be independent from you as they work together to solve problems. Be explicit about how exactly they should work together and behave. Stress to them that the ability to work collaboratively fosters incredible experiences but that centers are a privilege that they must earn with responsible behavior. Write these goals somewhere for easy reference. Setting up the Classroom With your learning center materials prepared, you can arrange your room to accommodate new spaces. The way you choose to set up your centers ultimately depends on the size of your class and number of students but the following tips can be applied to any classroom. Groups should not exceed five students. This makes it possible for students to complete tasks and move easily through the centers.Get creative with the setup. Dont be afraid to use rugs, libraries, and even hallways for your centers. Students are flexible and enjoy experiencing learning in new ways and from new angles, so dont hesitate to have some working on the floor and some standing up if the activities allow for this. Keep materials organized. Its not enough to just keep them in one place, you also need a system for making materials easy for students to find and keeping the supplies together after they have been used. Utilize baskets, folders, and totes for easy organization and efficiency. Make a schedule. Assign each student a group to rotate with and center where they will begin and end. Give each group and center a color/shape and number to help children know where to go next.Provide cleanup time. After each center is completed, give students time to return materials to thei r places for the next group and a place to turn in their completed center work. This makes it easier to collect all finished work at once. Introducing Centers to Students Take time to very explicitly introduce the new centers and discuss rules with your class. Students must understand the expectations of center work before beginning—this ensures that your time can be spent supporting learning. Before you begin, clearly explain (and post somewhere in the classroom) expected behavior during centers and the consequences of not meeting these expectations. Then, introduce centers to your students by modeling the following steps. Use a timer that students can see and hear to keep track of time. Teach the students how you will get their attention during center time. Try some of these call-and-responses.Point out or physically bring the students to each center to explain them one at a time.Show students where the directions and all other materials are located at every center (Note: Materials should be in about the same place for each of them).Explain in detail the purpose of each activity they will be working on—This is what you should learn at this center.Model completing the work that students will be doing. Show only enough that students understand and feel free to skip very straightforward activities to spend more time on the more challenging ones.Demonstrate how to clean up the center and rotate to the next one when the timer goes off. Be sure to intersperse your directions with student practice. Pause after each point to make sure they understand, then allow a volunteer or group of volunteers to demonstrate the steps after youve modeled them—finding the materials, beginning the activity, responding when the teacher calls for their attention, cleaning up the center, and rotating to the next one—while the class observes. Then, allow the whole class to practice this once or twice and they will be ready to start on their own.

Wednesday, May 6, 2020

The West Unique, Not Universal, By Samuel P. Huntington

In Samuel P. Huntington’s article â€Å"The West: Unique, Not Universal,† he addresses his audience with a very controversial question: Is Western Culture universal or unique? Huntington elaborately opens up this question with research and examples to explain and persuade readers that the West will never be a universal culture for all, but rather a unique culture that will be accepted by those who appreciate it. For decades now, historians and scholars have debated with one another to determine who is right and wrong. However, from a handful of articles from different scholars, Samuel Huntington’s statement that the West is unique rather than universal is supported and even further elaborated on by these particular sources. A common understanding between all the sources, that must be noted, is that a civilization’s culture is not comprised of material goods but rather their culmination of their religion(s), values, language(s) and traditions. While al though there are scholars out their that negate the West is unique, a large amount of scholars still argue and strengthen Huntington’s argument that the West has unique and exclusive characteristics that make them distinctive and rare. Samuel P. Huntington was a brilliant student and political scientist who wrote numerous articles and is most notably recognized for his novel â€Å"The Clash of Civilizations.† He attended college at Yale University and went on to get his PhD in political science. Moreover he was a Harvard professorShow MoreRelatedUniversal Human Rights? Essay1932 Words   |  8 Pagesnotorious for its explicit defiance of international human right norms. These norms, codified in the United Nation’s Universal Declaration of Human Rights (hereinafter, the UDHR), define human rights to be â€Å"inherent dignity and of the equal and inalienable rights of all members of the human family† (The Universal Declaration). 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Factor accumulation and innovation are only proximate causes of growth. In North and Thomas’s view, the fundamental explanation of comparative growth is diï ¬â‚¬erences in institutions. What are institutions exactly? North (1990, p. 3) oï ¬â‚¬ers the following deï ¬ nition: â€Å"InstitutionsRead MoreStephen P. Robbins Timothy A. Judge (2011) Organizational Behaviour 15th Edition New Jersey: Prentice Hall393164 Words   |  1573 Pages Organizational Behavior This page intentionally left blank Organizational Behavior EDITION 15 Stephen P. Robbins —San Diego State University Timothy A. Judge —University of Notre Dame i3iEi35Bj! Boston Columbus Indianapolis New York San Francisco Upper Saddle River Amsterdam Cape Town Dubai London Madrid Milan Munich Paris Montreal Toronto Delhi Mexico City Sao Paulo Sydney Hong Kong Seoul Singapore Taipei Tokyo Editorial Director: Sally Yagan Director of Editorial Services:

Sacred Places Essay Example For Students

Sacred Places Essay The World Trade Center: A Sacred Site R. Clark, J. Frazier July 4, 2010 Greg Underwood University of Phoenix The World Trade Center: Sacred Site Myths, while imagined, have their own explanations of the divine, that to the faithful and those who take the myth on faith, see as true, sacred and unquestioned. For those who do not see myths as religion and the lore and stories in it mere stories, events and elements in it are curiously close to the beliefs and persuasive elements of the philosophies or religion the person follows. Take for example current world religions elements of god, evil, goodness, light, dark, motherhood, piety, divine appointment, determinism they are all part of the Pantheon. Remember, that back in the period when the stories and tales we now know as myths were the standard, they were seen and treated by the civilization or culture that followed them as the truth, the established knowledge and explanation of their world, their reality and their role and place in it. Each myth, each pantheon of gods had their own sacred places. Like dwellings to humans, these sacred places were either their abodes or locations that held great significance to them due to events and roles that played out in it. There are different types of sacred sights. Despite their differences they are united by common elements. Sacred sites allow the people of a specific culture transcend time space, moving them to a distant, sacred space. Sometimes this is through historic retellings of actual events and sometimes it is through the imagination of things that cannot be proven to have happened. They are the sites where important things happened, either through divine or human agency (Leonard McClure, 2004). Some sacred places are sites for mourning. Let us, for the purpose of discussion, consider religion as an evolution or an expression of established myths. The Wailing Wall in Jerusalem and the Golgotha, the hill and site where Jesus Christ was crucified, is a place of mourning but at the same time a place of divine sanctity as events of the divine that are important in the Pantheon, erformed on, for or by important figures in the pantheon happened there (wcg. org, 2008). Jesus Christs crucifixion is central to Christian theology. It is by his death that Man is saved, an offering to God and to humanity. Without the death of Christ, in such a cruel and gruesome manner, the Christianity we know today wont exist as it is where Jesus Christ transcends from mortal to divine. Hence, the place he was cruelly put to death, the cross he was nailed to, his shroud, the nails, the crown of thorns, the city where it happened and all the characters evil and good that placed a part in it, they are all important in the telling and the sanctity of the event with the place, the city of Jerusalem and the hill of Golgotha determined in the larger Christian pantheon as absolutely and unquestionably sacred (wikipedia. org, 2010). Now, lets take a look at other sacred places the temples of the Roman Gods, the temples and pyramids of Egyptian pharaohs, the ancient Celtic locations known as Stonehenge, that used to host worship and celebratory ceremonies, the ancient temples of the Olmecs, the Aztecs and the Incas and important places of worship of the American Indians are only among the many. Many of these places are not places of mourning but also of celebration. However, when worship and celebration happens, it only means remembrance, prayers and giving importance to a set of beliefs. .u1f4234faa0212beaf7ad7d59b86cce4d , .u1f4234faa0212beaf7ad7d59b86cce4d .postImageUrl , .u1f4234faa0212beaf7ad7d59b86cce4d .centered-text-area { min-height: 80px; position: relative; } .u1f4234faa0212beaf7ad7d59b86cce4d , .u1f4234faa0212beaf7ad7d59b86cce4d:hover , .u1f4234faa0212beaf7ad7d59b86cce4d:visited , .u1f4234faa0212beaf7ad7d59b86cce4d:active { border:0!important; } .u1f4234faa0212beaf7ad7d59b86cce4d .clearfix:after { content: ""; display: table; clear: both; } .u1f4234faa0212beaf7ad7d59b86cce4d { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u1f4234faa0212beaf7ad7d59b86cce4d:active , .u1f4234faa0212beaf7ad7d59b86cce4d:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u1f4234faa0212beaf7ad7d59b86cce4d .centered-text-area { width: 100%; position: relative ; } .u1f4234faa0212beaf7ad7d59b86cce4d .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u1f4234faa0212beaf7ad7d59b86cce4d .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u1f4234faa0212beaf7ad7d59b86cce4d .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(; position: absolute; right: 0; top: 0; } .u1f4234faa0212beaf7ad7d59b86cce4d:hover .ctaButton { background-color: #34495E!important; } .u1f4234faa0212beaf7ad7d59b86cce4d .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u1f4234faa0212beaf7ad7d59b86cce4d .u1f4234faa0212beaf7ad7d59b86cce4d-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u1f4234faa0212beaf7ad7d59b86cce4d:after { content: ""; display: block; clear: both; } READ: The American Opportunity EssayNow, by mourning, those who come to mourn remember all the good things about a person, an event or a relationship hence the loss is difficult and sad. They mourn to pray for, give thanks to as well as celebrate and give importance to the object of their mourning. Hence, in Christian churches, a mass is held to celebrate and mourn a departed before his/her body is entered into the tomb. Now in modern America, can it be said that the former site of the World Trade Center is an emergent sacred location? Like Troy in Homers Iliad and Odyssey (www. imelessmyths. com, 1999), it was cruelly destroyed and burnt down to the ground unsuspecting individ uals going about their lives attacked upon in stealth by an angry enemy wishing to terrorize with fear a nation (in comparison to Troy, considered a sacred place in the pantheon of Greek mythology, as proven in the digs at the Greek city of Pergamum in what is now Turkey). Granted, the terrorists did not have the supposed fleets of Greek navy and regiments of warriors and soldiers representing nations. However, their attack was aimed to settle a score, to destroy, harm and if possible, raze to the ground Troy over several disputes and grievances over territory, politics, wealth and a woman, Helen. In comparison, the Al Qaeda terrorists motivations are not far off politics, ideology, religion and territory. The World Trade Center was originally a venture to revitalize Lower Manhattan. The Port Authority thought this idea of consolidated world trade would bring a greater flow of commerce and traffic through the port. It was a seven building structure that would house offices above west Hudson stop on the PATH Line (WTC, 2010). It can be assumed that the original team of men and women who envisioned such a bright future for the building could not have expected the World Trade Center would come to stand for far more. On September 11th, 2001, the World Trade Center was destroyed by terrorists who flew two commercial jets into the twin towers. On September 12th, amidst the twisted wreckage and a mourning nation, a sacred site was born. The destruction of the World Trade Center opened a new chapter in global politics and conflict resulting to a continuing war on a global scale that resulted to change in regimes, associations and political leadership in the Middle East (Iraq) and Central Asia (Afghanistan) and caused several similarly themed events the world over (consider the Bali Bombings). It divided people by religion and belief, as well as united those who stand by view and faith, as well as realigned political affiliations and rearranged legislation from domestic to global agencies. Most of all, soldiers, civilians and fighters lost their lives, causing families and communities to mourn and give a certain sense of importance, negative or positive, to the site where it all began the former site of the Twin Towers in New York. The loss of lives in the building itself is significant. Families and friends still come to the site regularly to pray for and to mourn those who perished, including families of people who lost their lives in the preceding war. The site has become sacred as the spiritual elements of their passing become a source of hope and inspiration to those who mourn them, celebrating their lives when they were still around. Much like Jerusalem, the site has become sacred due to the events that happened in it and the meaning attached to the event and the people involved. In conclusion The World Trade Center has come to stand for more than just a building that emphasizes global commerce. It is more than a way for the Port Authority to increase its ridership. And it is far more than a way to revitalize a dying neighborhood. .u342a54094ab596b2a6dbd5f1310c82be , .u342a54094ab596b2a6dbd5f1310c82be .postImageUrl , .u342a54094ab596b2a6dbd5f1310c82be .centered-text-area { min-height: 80px; position: relative; } .u342a54094ab596b2a6dbd5f1310c82be , .u342a54094ab596b2a6dbd5f1310c82be:hover , .u342a54094ab596b2a6dbd5f1310c82be:visited , .u342a54094ab596b2a6dbd5f1310c82be:active { border:0!important; } .u342a54094ab596b2a6dbd5f1310c82be .clearfix:after { content: ""; display: table; clear: both; } .u342a54094ab596b2a6dbd5f1310c82be { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u342a54094ab596b2a6dbd5f1310c82be:active , .u342a54094ab596b2a6dbd5f1310c82be:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u342a54094ab596b2a6dbd5f1310c82be .centered-text-area { width: 100%; position: relative ; } .u342a54094ab596b2a6dbd5f1310c82be .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u342a54094ab596b2a6dbd5f1310c82be .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u342a54094ab596b2a6dbd5f1310c82be .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(; position: absolute; right: 0; top: 0; } .u342a54094ab596b2a6dbd5f1310c82be:hover .ctaButton { background-color: #34495E!important; } .u342a54094ab596b2a6dbd5f1310c82be .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u342a54094ab596b2a6dbd5f1310c82be .u342a54094ab596b2a6dbd5f1310c82be-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u342a54094ab596b2a6dbd5f1310c82be:after { content: ""; display: block; clear: both; } READ: A Streetcar Named Desire Coursework EssayThe images of the twin towers, broken, twisted and smoking are burned in the American cultural consciousness. The remains of the building has been cleared away, so that a new six building structure and a memorial can be re-built in the original’s place. But the site will never again just be an office building or a stop on the Port Authority Trans-Hudson line. It will forever be a reminder to the American people that freedom always has a cost, and that cost can be tallied in lives. That very memory of the World Trade Center provides solidarity for many different people of different lifestyles. It reminds us of our fragility and brings the realities of our global neighborhood in a harsh way. It moves us beyond the here and now and unites us against a common threat. It moves us to great heights of compassion and sacrifice and reminds us of the all to human flaws that we as a people struggle with. We are not so unlike our Greek brethren, nor are our modern sacred places so different from their ancient relative, Troy. References Information retrieved on July 1, 2010, from experiencefestival. com/a/Sacred_Places. Information retrieved on July 1, 2010, from www. en. wikipedia. org/wiki/Presentation_of_Jesus_at_the_Temple Information retrieved on July 1, 2010, from http://www. wcg. org/lit/jesus/golgotha. htm. Information retrieved on July 1, 2010, from http://www. timelessmyths. com/classical/ Leonard, S. , McClure, M. (2004). Myth and knowing. An introduction to world mythology . Retrieved from  https://ecampus. phoenix. edu/content/eBookLibrary2/ content/eReader. aspx. (2010). World Trade Center. Retrieved from http://www. wtc. com/about/wtchistory-wtc- timeline